Completed PHASE3 INTERVENTIONAL 2-arm NCT00002708

Radiation Therapy With or Without Radiosurgery in Treating Patients With Brain Metastases

A PHASE III TRIAL COMPARING WHOLE BRAIN IRRADIATION WITH VERSUS WITHOUT STEREOTACTIC RADIOSURGERY BOOST FOR PATIENTS WITH ONE TO THREE UNRESECTED BRAIN METASTASES

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Cancer

Interventions radiation therapy stereotactic radiosurgery surgical procedure

Updated 6 times since 2017 Last updated: Nov 18, 2013 Started: Jan 31, 1996 Primary completion: Jan 31, 2002 Completion: Dec 31, 2004

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00002708, this PHASE3 trial focuses on Metastatic Cancer and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 6 times since 1996, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

6 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Completed PHASE3

First recorded

Jan 1996

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Albuquerque, United States , Allentown, United States , Amarillo, United States , Anchorage, United States , Anderson, United States , Ann Arbor, United States , Annapolis, United States , Arlington Heights, United States and 188 more locations