Completed PHASE3 INTERVENTIONAL NCT00003057

Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal Cancer

Randomized Trial of High-Dose Versus Conventional Dose Octreotide Acetate Versus Loperamide in the Treatment of Chemotherpay-Related Diarrhea in Patients With Colorectal Cancer

Sponsor: Cancer and Leukemia Group B

Conditions Colorectal Cancer Diarrhea

Interventions loperamide hydrochloride octreotide acetate

Updated 9 times since 2017 Last updated: Jun 14, 2023 Started: Mar 26, 1997 Primary completion: May 31, 2000

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Colorectal Cancer and Diarrhea and is currently completed. Cancer and Leukemia Group B leads this study, which shows 9 recorded versions since 1997 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jul 2023 — Jul 2024 [monthly]

Completed PHASE3
May 2023 — Jul 2023 [monthly]

Completed PHASE3

▶ Show 4 earlier versions

Jan 2021 — May 2023 [monthly]

Completed PHASE3
Dec 2020 — Jan 2021 [monthly]

Completed PHASE3
Jun 2018 — Dec 2020 [monthly]

Completed PHASE3
Jan 2017 — Jun 2018 [monthly]

Completed PHASE3

First recorded

Mar 1997

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Cancer and Leukemia Group B
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)
SWOG Cancer Research Network

Data source: Eastern Cooperative Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Boston, United States , Burlington, United States , Chapel Hill, United States , Charleston, United States , Chicago, United States , Columbia, United States , Durham, United States , Iowa City, United States , La Jolla, United States and 17 more locations