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Completed PHASE3 INTERVENTIONAL 2-arm NCT00003140

Letrozole After Tamoxifen in Treating Women With Breast Cancer

A Phase III Randomized Double Blind Study of Letrozole Versus Placebo in Women With Primary Breast Cancer Completing Five or More Years of Adjuvant Tamoxifen

Sponsor: Cancer and Leukemia Group B

Conditions Breast Cancer
Interventions letrozole placebo
Updated 10 times since 2017 Last updated: Sep 15, 2020 Started: Aug 24, 1998 Primary completion: Aug 22, 2003 Completion: Oct 31, 2003
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00003140, this PHASE3 trial focuses on Breast Cancer and remains completed. Sponsored by Cancer and Leukemia Group B, it has been updated 10 times since 1998, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotCompleted~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotCompleted~Jun 2018 – ~Oct 2020 · 28 months · monthly snapshotCompleted~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshotCompleted~Jan 2021 – ~Oct 2022 · 21 months · monthly snapshotCompleted~Oct 2022 – ~May 2023 · 7 months · monthly snapshotCompleted~May 2023 – ~Jul 2024 · 14 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 11 months · monthly snapshotCompleted

Change History

10 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. May 2023 — Jul 2024 [monthly]

    Completed PHASE3

  5. Oct 2022 — May 2023 [monthly]

    Completed PHASE3

▶ Show 5 earlier versions

  1. Jan 2021 — Oct 2022 [monthly]

    Completed PHASE3

  2. Oct 2020 — Jan 2021 [monthly]

    Completed PHASE3

  3. Jun 2018 — Oct 2020 [monthly]

    Completed PHASE3

  4. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE3

  5. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE3

    First recorded

Aug 1998

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cancer and Leukemia Group B
  • ETOP IBCSG Partners Foundation
  • Eastern Cooperative Oncology Group
  • European Organisation for Research and Treatment of Cancer - EORTC
  • NCIC Clinical Trials Group
  • National Cancer Institute (NCI)
  • North Central Cancer Treatment Group
  • SWOG Cancer Research Network
Data source: Canadian Cancer Trials Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Barrie, Canada , Charlottetown, Canada , Gatineau, Canada , Greater Sudbury, Canada , Halifax, Canada , Hamilton, Canada , Kelowna, Canada , Kingston, Canada , Lethbridge, Canada , London, Canada and 29 more locations