High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer
Pan-European Trials in Adjuvant Colon Cancer (PETACC-2): Randomized Phase III Intergroup Trial of High-Dose Infusional 5-FU (+ or - Folinic Acid) Versus Standard Bolus 5-FU/Folinic Acid
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
A PHASE3 clinical study on Colorectal Cancer, this trial is completed. The trial is conducted by European Organisation for Research and Treatment of Cancer - EORTC and has accumulated 7 data snapshots since 1999. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.
Status Flow
Change History
7 versions recorded-
Oct 2025 — Present [monthly]
Completed PHASE3
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Sep 2025 — Oct 2025 [monthly]
Completed PHASE3
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Sep 2024 — Sep 2025 [monthly]
Completed PHASE3
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE3
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Jan 2021 — Jul 2024 [monthly]
Completed PHASE3
▶ Show 2 earlier versions
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Jun 2018 — Jan 2021 [monthly]
Completed PHASE3
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Jan 2017 — Jun 2018 [monthly]
Completed PHASE3
First recorded
Mar 1999
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- European Organisation for Research and Treatment of Cancer - EORTC
- Federation Francophone de Cancerologie Digestive
- Grupo Espanol Tratamiento Tumores Digestivos
- Robert Roessle Klinik
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Albacete, Spain , Alcoi Alicante, Spain , Alicante, Spain , Angers, France , Antwerp, Belgium , Badalona, Spain , Barbastro, Spain , Barcelona, Spain , Bayonne, France , Belfort, France and 62 more locations