Completed PHASE1 INTERVENTIONAL 1-arm NCT00008450

Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant

Induction of Mixed Hematopoietic Chimerism in Patients With Severe Combined Immunodeficiency Disorders Using Allogeneic Bone Marrow and Post-Transplant Immunosuppression With Cyclosporine and Mycophenolate Mofetil

Sponsor: Fred Hutchinson Cancer Center

Conditions Adenosine Deaminase Deficiency Autosomal Recessive Disorder Immune System Disorder Purine-Nucleoside Phosphorylase Deficiency Severe Combined Immunodeficiency Severe Combined Immunodeficiency With Absence of T and B Cells X-Linked Severe Combined Immunodeficiency

Interventions Allogeneic Bone Marrow Transplantation Cyclosporine Laboratory Biomarker Analysis Mycophenolate Mofetil Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation Total-Body Irradiation

Updated 10 times since 2017 Last updated: Jul 26, 2019 Started: Aug 11, 1997 Primary completion: Oct 25, 2011 Completion: Dec 26, 2018

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00008450, this PHASE1 trial focuses on Adenosine Deaminase Deficiency and Autosomal Recessive Disorder and remains completed. Sponsored by Fred Hutchinson Cancer Center, it has been updated 10 times since 1997, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

10 versions recorded

Sep 2024 — Present [monthly]

Completed PHASE1
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1
May 2022 — Jul 2024 [monthly]

Completed PHASE1
Jan 2021 — May 2022 [monthly]

Completed PHASE1
Aug 2019 — Jan 2021 [monthly]

Completed PHASE1

Status: Active Not Recruiting → Completed

▶ Show 5 earlier versions

Aug 2018 — Aug 2019 [monthly]

Active Not Recruiting PHASE1
Jun 2018 — Aug 2018 [monthly]

Active Not Recruiting PHASE1
Aug 2017 — Jun 2018 [monthly]

Active Not Recruiting PHASE1
Feb 2017 — Aug 2017 [monthly]

Active Not Recruiting PHASE1
Jan 2017 — Feb 2017 [monthly]

Active Not Recruiting PHASE1

First recorded

Aug 1997

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Fred Hutchinson Cancer Center
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)

Data source: Fred Hutchinson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Seattle, United States