Completed PHASE3 INTERVENTIONAL 2-arm NCT00047008

Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer

A Phase III Trial of Concurrent Radiation and Chemotherapy for Advanced Head and Neck Carcinomas

Sponsor: NRG Oncology

Interventions Accelerated fractionation radiation therapy Conventional surgery for select patients Standard fractionation RT cisplatin

Updated 12 times since 2017 Last updated: Jul 3, 2023 Started: Jul 31, 2002 Primary completion: Jun 30, 2010 Completion: May 20, 2022

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Head and Neck Cancer, this trial is completed. The trial is conducted by NRG Oncology and has accumulated 12 data snapshots since 2002. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

12 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Aug 2023 — Jul 2024 [monthly]

Completed PHASE3
Jul 2022 — Aug 2023 [monthly]

Completed PHASE3

Status: Unknown Status → Completed

▶ Show 7 earlier versions

Jan 2021 — Jul 2022 [monthly]

Unknown Status PHASE3
Dec 2020 — Jan 2021 [monthly]

Unknown Status PHASE3
Jun 2019 — Dec 2020 [monthly]

Unknown Status PHASE3

Status: Active Not Recruiting → Unknown Status
Jun 2018 — Jun 2019 [monthly]

Active Not Recruiting PHASE3
Jul 2017 — Jun 2018 [monthly]

Active Not Recruiting PHASE3
Feb 2017 — Jul 2017 [monthly]

Active Not Recruiting PHASE3
Jan 2017 — Feb 2017 [monthly]

Active Not Recruiting PHASE3

First recorded

Jul 2002

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

NRG Oncology
National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abington, United States , Akron, United States , Amarillo, United States , Anderson, United States , Ann Arbor, United States , Annapolis, United States , Arlington Heights, United States , Asheboro, United States , Atlanta, United States , Baton Rouge, United States and 134 more locations