deltatrials
Completed PHASE2 NCT00066248

Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment

The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia

Sponsor: National Cancer Institute (NCI)

Conditions Brain Tumor Cachexia Central Nervous System Tumors Leukemia Lymphoma Myelodysplastic Syndromes Myelodysplastic/Myeloproliferative Diseases Unspecified Childhood Solid Tumor, Protocol Specific
Interventions cyproheptadine hydrochloride megestrol acetate
Updated 7 times since 2017 Last updated: Jan 31, 2014 Started: Jun 30, 2003 Primary completion: Aug 31, 2007 Completion: Aug 31, 2007

Listed as NCT00066248, this PHASE2 trial focuses on Brain Tumor and Cachexia and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 7 times since 2003, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Change History

7 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE2

  5. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE2

▶ Show 2 earlier versions

  1. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE2

  2. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE2

    First recorded

Jun 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • University of South Florida
Data source: University of South Florida

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States, Augusta, United States, Boston, United States, Buffalo, United States, Burlington, United States, Charlotte, United States, Columbus, United States, Dayton, United States, Detroit, United States, Gainesville, United States and 28 more location s