Completed PHASE2 INTERVENTIONAL 1-arm NCT00076102

Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas

Phase II Trial of Pirfenidone in Children, Adolescents, and Young Adults With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas

Sponsor: National Cancer Institute (NCI)

Conditions Neurofibroma, Plexiform Neurofibromatosis 1

Interventions Pirfenidone

Updated 7 times since 2017 Last updated: Apr 19, 2018 Started: Jul 21, 2004 Primary completion: Apr 1, 2010 Completion: Apr 1, 2010

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Neurofibroma, Plexiform and Neurofibromatosis 1, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 7 data snapshots since 2004. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2
Jun 2018 — Jan 2021 [monthly]

Completed PHASE2

▶ Show 2 earlier versions

May 2018 — Jun 2018 [monthly]

Completed PHASE2
Jan 2017 — May 2018 [monthly]

Completed PHASE2

First recorded

Jul 2004

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Cancer Institute (NCI)

Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Bethesda, United States , Birmingham, United States , Boston, United States , Chicago, United States , Cleveland, United States , Houston, United States , New York, United States , Philadelphia, United States , Pittsburgh, United States and 5 more locations