deltatrials
Terminated PHASE1 NCT00094978

Depsipeptide/Flavopiridol Infusion for Cancers of the Lungs, Esophagus, Pleura, Thymus or Mediastinum

Phase I Study of Sequential Depsipeptide/Flavopiridol Infusion for Malignancies Involving Lungs, Esophagus, Pleura, Thymus or Mediastinum

Sponsor: National Cancer Institute (NCI)

Conditions Carcinoma, Non-Small-Cell Lung Carcinoma, Small Cell Esophageal Neoplasms Mesothelioma
Interventions Depsipeptide Flavopiridol (alvocidib)
Updated 22 times since 2017 Last updated: Dec 11, 2019 Started: Oct 25, 2004 Primary completion: May 20, 2013 Completion: May 20, 2013

A PHASE1 clinical study on Carcinoma, Non-Small-Cell Lung and Carcinoma, Small Cell, this trial is terminated or withdrawn. The trial is conducted by National Cancer Institute (NCI) and has accumulated 22 data snapshots since 2004. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 19 months · monthly snapshot

Change History

22 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Terminated PHASE1

  4. Jan 2020 — Jan 2021 [monthly]

    Terminated PHASE1

  5. Dec 2019 — Jan 2020 [monthly]

    Terminated PHASE1

▶ Show 17 earlier versions

  1. Nov 2019 — Dec 2019 [monthly]

    Terminated PHASE1

  2. Oct 2019 — Nov 2019 [monthly]

    Terminated PHASE1

  3. Jul 2019 — Oct 2019 [monthly]

    Terminated PHASE1

  4. Jun 2019 — Jul 2019 [monthly]

    Terminated PHASE1

  5. May 2019 — Jun 2019 [monthly]

    Terminated PHASE1

  6. Apr 2019 — May 2019 [monthly]

    Terminated PHASE1

  7. Mar 2019 — Apr 2019 [monthly]

    Terminated PHASE1

  8. Feb 2019 — Mar 2019 [monthly]

    Terminated PHASE1

  9. Jan 2019 — Feb 2019 [monthly]

    Terminated PHASE1

  10. Nov 2018 — Jan 2019 [monthly]

    Terminated PHASE1

  11. Oct 2018 — Nov 2018 [monthly]

    Terminated PHASE1

  12. Sep 2018 — Oct 2018 [monthly]

    Terminated PHASE1

  13. Aug 2018 — Sep 2018 [monthly]

    Terminated PHASE1

  14. Jul 2018 — Aug 2018 [monthly]

    Terminated PHASE1

  15. Jun 2018 — Jul 2018 [monthly]

    Terminated PHASE1

  16. Feb 2017 — Jun 2018 [monthly]

    Terminated PHASE1

  17. Jan 2017 — Feb 2017 [monthly]

    Terminated PHASE1

    First recorded

Oct 2004

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations