Completed PHASE3 INTERVENTIONAL 2-arm NCT00198510

Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage

Phase III Safety and Efficacy Study of Vitrase (Ovine Hyaluronidase) for Ophthalmic Intravitreal Injection for Clearance of Severe Vitreous Hemorrhage

Sponsor: Bausch & Lomb Incorporated

Conditions Diabetic Retinopathy Vitreous Hemorrhage

Interventions Vitrase

Updated 7 times since 2017 Last updated: Mar 14, 2013 Started: Nov 30, 1998 Primary completion: Sep 30, 2001 Completion: Mar 31, 2003

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Diabetic Retinopathy and Vitreous Hemorrhage and is currently completed. Bausch & Lomb Incorporated leads this study, which shows 7 recorded versions since 1998 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Nov 1998

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Bausch & Lomb Incorporated

Data source: Bausch & Lomb Incorporated

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Altamonte Springs, United States , Baltimore, United States , Bethesda, United States , Beverly Hills, United States , Boston, United States , Charlotte, United States , Chicago, United States , Chula Vista, United States , Cleveland, United States , Col. Obrera, Mexico and 56 more locations