Completed PHASE2 INTERVENTIONAL NCT00221000

Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis (RA-1)

A Phase II, Multicenter, Randomized, Double-blind, Sham Pheresis-controlled, Study of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis in Patients Who Have an Inadequate Response to Disease Modifying Antirheumatic Drugs and Biological Agents

Sponsor: Mallinckrodt

Conditions Rheumatoid Arthritis

Interventions Extracorporeal Photopheresis Methoxsalen

Updated 7 times since 2017 Last updated: Oct 18, 2016 Started: Aug 31, 2003 Primary completion: Oct 31, 2006 Completion: Nov 30, 2006

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00221000, this PHASE2 trial focuses on Rheumatoid Arthritis and remains completed. Sponsored by Mallinckrodt, it has been updated 7 times since 2003, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2
Jun 2018 — Jan 2021 [monthly]

Completed PHASE2

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

Aug 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Mallinckrodt

Data source: Mallinckrodt

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bad Brückenau, Germany , Berlin, Germany , Bloemfontein, South Africa , Bratislava, Slovakia , Brussels, Belgium , Cape Town, South Africa , Cologne, Germany , Dallas, United States , Diepenbeek, Belgium , Erlangen, Germany and 21 more locations