Completed PHASE2 INTERVENTIONAL 2-arm NCT00285207

Safety and Efficacy of A-007 Topical Gel in the Treatment of High-Grade Squamous Intraepithelial Lesions (HSIL) of the Cervix

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Trial of the Use of 4,4'-Dihydroxybenzophenone-2,4-Dinitrophenyl-hydrazone (A-007) Topical Gel in the Treatment of High-Grade Squamous Intraepithelial Lesions (HSIL) of the Cervix

Sponsor: Tigris Pharmaceuticals

Conditions Cervical Intraepithelial Neoplasia Uterine Cervical Dysplasia

Interventions A007 placebo

Updated 7 times since 2017 Last updated: Sep 23, 2010 Started: Jan 31, 2006 Primary completion: Apr 30, 2008 Completion: Jun 30, 2008

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Cervical Intraepithelial Neoplasia and Uterine Cervical Dysplasia and is currently completed. Tigris Pharmaceuticals leads this study, which shows 7 recorded versions since 2006 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2
Jun 2018 — Jan 2021 [monthly]

Completed PHASE2

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

Jan 2006

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Tigris Pharmaceuticals

Data source: Tigris Pharmaceuticals

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Allentown, United States , Atlanta, United States , Augusta, United States , Austin, United States , Birmingham, United States , Boynton Beach, United States , Carmichael, United States , Cincinnati, United States , Colton, United States , Columbia, United States and 18 more locations