Completed PHASE3 INTERVENTIONAL 3-arm NCT00286481

Efficacy of Lapaquistat Acetate Alone or Combined With Simvastatin in Subjects With Hypercholesterolemia

A Double-Blind, Randomized, Placebo-Controlled Factorial Study to Evaluate the Efficacy and Safety of Lapaquistat and Simvastatin Alone and in Combination in Subjects With Hypercholesterolemia

Sponsor: Takeda

Conditions Hypercholesterolemia

Interventions Lapaquistat acetate and simvastatin Simvastatin

Updated 7 times since 2017 Last updated: May 23, 2012 Started: Mar 31, 2006 Primary completion: May 31, 2007 Completion: May 31, 2007

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00286481, this PHASE3 trial focuses on Hypercholesterolemia and remains completed. Sponsored by Takeda, it has been updated 7 times since 2006, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Mar 2006

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Takeda

Data source: Takeda

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abbotsford, Canada , Arlington Heights, United States , Bartlesville, United States , Beaver, United States , Beverly Hills, United States , Chandler, United States , Chicago, United States , Cincinnati, United States , Colorado Springs, United States , Columbus, United States and 56 more locations