Completed PHASE3 INTERVENTIONAL 2-arm NCT00289211

C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks

LEVP2005-1/Part A: A Double-blind, Placebo-Controlled, Clinical Study to Investigate the Efficacy and Safety of Purified C1 Esterase Inhibitor (Human) for the Treatment of HAE in Acute Attacks

Sponsor: Shire

Conditions Hereditary Angioedema

Interventions C1 esterase inhibitor [human] (C1INH-nf) Placebo (saline)

Updated 10 times since 2017 Last updated: Jun 3, 2021 Started: Mar 14, 2005 Primary completion: Apr 13, 2007 Completion: Apr 13, 2007

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00289211, this PHASE3 trial focuses on Hereditary Angioedema and remains completed. Sponsored by Shire, it has been updated 10 times since 2005, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

10 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2023 — Jul 2024 [monthly]

Completed PHASE3
Dec 2022 — Jan 2023 [monthly]

Completed PHASE3

▶ Show 5 earlier versions

Sep 2021 — Dec 2022 [monthly]

Completed PHASE3
Jan 2021 — Sep 2021 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Mar 2005

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Shire

Data source: Takeda

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Baton Rouge, United States , Cincinnati, United States , Columbus, United States , Dallas, United States , Durham, United States , Evansville, United States , Falmouth, United States , Fargo, United States , Fort Lauderdale, United States and 27 more locations