Terminated PHASE3 INTERVENTIONAL 2-arm NCT00359424

Interventional Management of Stroke (IMS) III Trial (IMSIII)

Interventional Management of Stroke Trial (IMS III): A Phase III Clinical Trial Examining Whether a Combined Intravenous (IV) and Intra-Arterial (IA) Approach to Recanalization is Superior to Standard IV Rt-PA (Activase®) Alone

Sponsor: Joseph Broderick

Conditions Stroke

Interventions IV rt-PA alone endovascular therapy

Updated 8 times since 2017 Last updated: Nov 19, 2013 Started: Aug 31, 2006 Primary completion: Jul 31, 2012 Completion: Apr 30, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

NINDS/NIH-DSMB recommended halting trial due to futility, no safety concerns.

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This PHASE3 trial investigates Stroke and is currently terminated or withdrawn. Joseph Broderick leads this study, which shows 8 recorded versions since 2006 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Terminated PHASE3
Sep 2024 — Sep 2025 [monthly]

Terminated PHASE3
Jul 2024 — Sep 2024 [monthly]

Terminated PHASE3
Dec 2021 — Jul 2024 [monthly]

Terminated PHASE3
Jan 2021 — Dec 2021 [monthly]

Terminated PHASE3

▶ Show 3 earlier versions

Jun 2018 — Jan 2021 [monthly]

Terminated PHASE3
Feb 2017 — Jun 2018 [monthly]

Terminated PHASE3
Jan 2017 — Feb 2017 [monthly]

Terminated PHASE3

First recorded

Aug 2006

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Joseph Broderick
Medical University of South Carolina
National Institute of Neurological Disorders and Stroke (NINDS)
University of Calgary

Data source: University of Cincinnati

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abington, United States , Allentown, United States , Asheville, United States , Austin, United States , Badalona, Spain , Baltimore, United States , Barcelona, Spain , Basel, Switzerland , Birmingham, United States , Boston, United States and 51 more locations