Completed PHASE1 NCT00365001

A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis.

A Randomized, Open-label Study to Assess the Pharmacokinetics of Simvastatin and Methotrexate in Combination With Tocilizumab in Patients With Rheumatoid Arthritis.

Sponsor: Hoffmann-La Roche

Conditions Rheumatoid Arthritis

Interventions Methotrexate Simvastatin tocilizumab [RoActemra/Actemra]

Updated 7 times since 2017 Last updated: Jun 10, 2010 Completion: Apr 30, 2008

This PHASE1 trial investigates Rheumatoid Arthritis and is currently completed. Hoffmann-La Roche leads this study, which shows 7 recorded versions since 2026 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE1
Sep 2024 — Sep 2025 [monthly]

Completed PHASE1
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1
Jan 2021 — Jul 2024 [monthly]

Completed PHASE1
Jun 2018 — Jan 2021 [monthly]

Completed PHASE1

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE1
Jan 2017 — Feb 2017 [monthly]

Completed PHASE1

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Hoffmann-La Roche

Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Anniston, United States , Austin, United States , Christchurch, New Zealand , Duncansville, United States , Jacksonville, United States , Little Rock, United States , Oklahoma City, United States , Omaha, United States , Palm Harbor, United States , Royal Oak, United States and 1 more location