deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT00380406

PROtecting Ovaries and Fertility During Chemotherapy - The PROOF Trial (PROOF)

PROtecting Ovaries and Fertility During Chemotherapy - The PROOF Trial: A Randomized Controlled Trial of Gonadotropin Releasing Hormone Agonist (GnRHa) for Fertility Preservation in Oncology Patients

Sponsor: Canadian Institutes of Health Research (CIHR)

Conditions Cancer Fertility Preservation
Interventions Leuprolide acetate
Updated 8 times since 2017 Last updated: Apr 3, 2017 Started: Jan 31, 2007 Primary completion: Jan 31, 2010 Completion: Apr 30, 2010
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Cancer and Fertility Preservation and is currently completed. Canadian Institutes of Health Research (CIHR) leads this study, which shows 8 recorded versions since 2007 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~May 2017 · 4 months · monthly snapshotCompleted~May 2017 – ~Jun 2018 · 13 months · monthly snapshotCompleted~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotCompleted~Apr 2025 – ~Jun 2025 · 2 months · monthly snapshotCompleted~Jun 2025 – present · 15 months · monthly snapshotCompleted

Change History

8 versions recorded

  1. Jun 2025 — Present [monthly]

    Completed PHASE3

  2. Apr 2025 — Jun 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Apr 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 3 earlier versions

  1. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE3

  2. May 2017 — Jun 2018 [monthly]

    Completed PHASE3

  3. Jan 2017 — May 2017 [monthly]

    Completed PHASE3

    First recorded

Jan 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Canadian Institutes of Health Research (CIHR)
  • Ottawa Hospital Research Institute
  • Queen's University
  • University of Ottawa
Data source: Ottawa Hospital Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations