Completed PHASE3 INTERVENTIONAL 3-arm NCT00401973

Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine

The Assessment of the Safety, Efficacy, and Practicality of an Algorithm Including Amantadine, Metformin and Zonisamide for the Prevention of Olanzapine-Associated Weight Gain in Outpatients With Schizophrenia

Sponsor: Eli Lilly and Company

Conditions Schizoaffective Disorders Schizophrenia

Interventions Wellness education amantadine metformin olanzapine zonisamide

Updated 7 times since 2017 Last updated: Sep 30, 2009 Started: Nov 30, 2006 Primary completion: Sep 30, 2008 Completion: Sep 30, 2008

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Schizoaffective Disorders and Schizophrenia and is currently completed. Eli Lilly and Company leads this study, which shows 7 recorded versions since 2006 — indicating limited longitudinal coverage. This study adds to the longitudinal dataset for psychiatric treatment development.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Nov 2006

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Eli Lilly and Company

Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bayamón, Puerto Rico , Beer Yaacov, Israel , Canton, United States , DeSoto, United States , Johnson City, United States , Memphis, United States , Mexico City, Mexico , Moscow, Russia , National City, United States , Ponce, Puerto Rico and 4 more locations