deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT00422084

Pyronaridine Artesunate (3:1) Versus Coartem® in P Falciparum Malaria Patients

A Phase III Comparative (Double-blind, Double-dummy) Randomised, Multi-centre Study to Assess the Efficacy of Pyronaridine Artesunate (180:60mg) Versus Coartem® (Artemether Lumefantrine) in Children & Adult Patients With Falciparum Malaria

Sponsor: Medicines for Malaria Venture

Conditions Malaria
Interventions Coartem® (artemether lumefantrine) Pyronaridine artesunate
Updated 9 times since 2017 Last updated: Oct 22, 2021 Started: Jan 31, 2007 Primary completion: Apr 30, 2008 Completion: May 31, 2008
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00422084, this PHASE3 trial focuses on Malaria and remains completed. Sponsored by Medicines for Malaria Venture, it has been updated 9 times since 2007, reflecting limited change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshotCompleted~Jun 2018 – ~May 2020 · 23 months · monthly snapshotCompleted~May 2020 – ~Jan 2021 · 8 months · monthly snapshotCompleted~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshotCompleted~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshotCompleted~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 12 months · monthly snapshotCompleted

Change History

9 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Dec 2021 — Jul 2024 [monthly]

    Completed PHASE3

  5. Oct 2021 — Dec 2021 [monthly]

    Completed PHASE3

▶ Show 4 earlier versions

  1. Jan 2021 — Oct 2021 [monthly]

    Completed PHASE3

  2. May 2020 — Jan 2021 [monthly]

    Completed PHASE3

  3. Jun 2018 — May 2020 [monthly]

    Completed PHASE3

  4. Jan 2017 — Jun 2018 [monthly]

    Completed PHASE3

    First recorded

Jan 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Medicines for Malaria Venture
  • Shin Poong Pharmaceuticals
Data source: Medicines for Malaria Venture

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations