Completed PHASE4 INTERVENTIONAL 2-arm NCT00430989

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).

Sponsor: Bayside Health

Conditions Coronary Artery Disease

Interventions Nitrous Oxide No Nitrous Oxide

Updated 10 times since 2017 Last updated: Dec 29, 2025 Started: Apr 30, 2007 Primary completion: Sep 30, 2013 Completion: Sep 30, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Coronary Artery Disease and is currently completed. Bayside Health leads this study, which shows 10 recorded versions since 2007 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

Change History

10 versions recorded

Feb 2026 — Present [monthly]

Completed PHASE4
Sep 2024 — Feb 2026 [monthly]

Completed PHASE4
Jul 2024 — Sep 2024 [monthly]

Completed PHASE4
Dec 2021 — Jul 2024 [monthly]

Completed PHASE4
Jan 2021 — Dec 2021 [monthly]

Completed PHASE4

▶ Show 5 earlier versions

Jan 2020 — Jan 2021 [monthly]

Completed PHASE4
Jul 2019 — Jan 2020 [monthly]

Completed PHASE4
Jun 2018 — Jul 2019 [monthly]

Completed PHASE4
Feb 2017 — Jun 2018 [monthly]

Completed PHASE4
Jan 2017 — Feb 2017 [monthly]

Completed PHASE4

First recorded

Apr 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Bayside Health
National Health and Medical Research Council, Australia

Data source: Bayside Health

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Melbourne, Australia