Cytokine Profiles in Children With Obstructive Sleep Apnea
Local and Systemic Cytokine Profiles in Children With Obstructive Sleep Apnea and Controls
Sponsor: University of Chicago
This NA trial investigates Obstructive Sleep Apnea Syndrome and is currently completed. University of Chicago leads this study, which shows 6 recorded versions since 2006 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Study Description(click to expand)We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood sample and portion of their tonsils after the induction of general anesthesia. The mononuclear cells will be isolated from both these tissues and stimulated with different markers and cytokines assayed and compared. We will also recruit patients with no symptoms of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the parents fill out a sleep questionnaire. We will then collect blood samples from these patients after the induction of anesthesia and examine the cytokine secretion profile and compare it to that of the children with OSA.
We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood sample and portion of their tonsils after the induction of general anesthesia. The mononuclear cells will be isolated from both these tissues and stimulated with different markers and cytokines assayed and compared. We will also recruit patients with no symptoms of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the parents fill out a sleep questionnaire. We will then collect blood samples from these patients after the induction of anesthesia and examine the cytokine secretion profile and compare it to that of the children with OSA.
Status Flow
Change History
6 versions recorded-
Sep 2024 — Present [monthly]
Completed NA
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Jul 2024 — Sep 2024 [monthly]
Completed NA
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Jun 2023 — Jul 2024 [monthly]
Completed NA
Status: Unknown Status → Completed
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Jan 2021 — Jun 2023 [monthly]
Unknown Status NA
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Jun 2018 — Jan 2021 [monthly]
Unknown Status NA
▶ Show 1 earlier version
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Jan 2017 — Jun 2018 [monthly]
Unknown Status NA
First recorded
Apr 2006
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- University of Chicago
For direct contact, visit the study record on ClinicalTrials.gov .