deltatrials
Completed PHASE3 INTERVENTIONAL 1-arm NCT00460512

An Efficacy, Safety And Tolerability Study of Flexibly Dosed Paliperidone Extended Release (ER) in Participants With Schizophrenia (PERFlexS)

An Open-label Prospective Trial to Explore the Tolerability, Safety and Efficacy of Flexibly Dosed Paliperidone ER in Subjects With Schizophrenia

Sponsor: Janssen-Cilag International NV

Conditions Schizophrenia
Interventions Paliperidone ER
Updated 22 times since 2017 Last updated: Apr 25, 2025 Started: Apr 25, 2007 Primary completion: Jan 22, 2009 Completion: Mar 4, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Schizophrenia and is currently completed. Janssen-Cilag International NV leads this study, which shows 22 recorded versions since 2007 — indicating substantial longitudinal coverage. This study adds to the longitudinal dataset for psychiatric treatment development.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~May 2017 · 2 months · monthly snapshot~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~May 2019 · 7 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Apr 2020 · 5 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jul 2024 · 39 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

22 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Mar 2025 — May 2025 [monthly]

    Completed PHASE3

  4. Sep 2024 — Mar 2025 [monthly]

    Completed PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

▶ Show 17 earlier versions

  1. Apr 2021 — Jul 2024 [monthly]

    Completed PHASE3

  2. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE3

  3. Jul 2020 — Jan 2021 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  4. Apr 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  5. Nov 2019 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  6. Jul 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  7. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  8. Oct 2018 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  9. Sep 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE3

  10. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE3

  11. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  12. Aug 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  13. Jul 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE3

  14. May 2017 — Jul 2017 [monthly]

    Active Not Recruiting PHASE3

  15. Mar 2017 — May 2017 [monthly]

    Active Not Recruiting PHASE3

  16. Feb 2017 — Mar 2017 [monthly]

    Active Not Recruiting PHASE3

  17. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Apr 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen-Cilag International NV
Data source: Janssen-Cilag International NV

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aalborg, Denmark , Aalen, Germany , Aarau, Switzerland , Achim, Germany , Alicante, Spain , Angra do Heroísmo, Portugal , Ankara, Turkey (Türkiye) , Antwerp, Belgium , Assen, Netherlands , Athens, Greece and 221 more locations