deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 6-arm NCT00463814

AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies

A Phase I, Open-Label, Multi-centre Study to Assess the Safety, Tolerability and Pharmacokinetics of a Solid Oral Dosage Formulation (Capsule) of AZD6244 in Patients With Advanced Solid Malignancies

Sponsor: AstraZeneca

Conditions Cancer Tumor
Interventions AZD6244
Updated 34 times since 2017 Last updated: Nov 12, 2025 Started: Mar 8, 2007 Primary completion: Jun 17, 2008 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00463814, this PHASE1 trial focuses on Cancer and Tumor and remains ongoing. Sponsored by AstraZeneca, it has been updated 34 times since 2007, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Jan 2019 · 4 months · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Apr 2020 · 3 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Oct 2020 · 3 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Mar 2022 · 3 months · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~Jun 2025 · 4 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 9 months · monthly snapshot

Change History

34 versions recorded

  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Feb 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Dec 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 29 earlier versions

  1. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  3. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Nov 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Aug 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  6. Apr 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Mar 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Dec 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  12. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  13. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1

  14. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  15. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1

  16. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  17. Jul 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1

  18. Apr 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1

  19. Jan 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE1

  20. Oct 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1

  21. Jul 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE1

  22. Apr 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1

  23. Jan 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE1

  24. Sep 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE1

  25. Jun 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE1

  26. Aug 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

  27. Jun 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE1

  28. Feb 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE1

  29. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Mar 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations