Completed PHASE3 INTERVENTIONAL 2-arm NCT00471445

Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients

Assessment of Topical Treatment Response With Amitriptyline and Ketamine: Combination Trial in Chemotherapy Peripheral Neuropathy (ATTRACT-CPN)

Sponsor: Gary Morrow

Conditions Neurotoxicity Pain Peripheral Neuropathy Unspecified Adult Solid Tumor, Protocol Specific

Interventions ketamine/amitriptyline NP-H cream placebo

Updated 8 times since 2017 Last updated: Oct 13, 2015 Started: Oct 31, 2007 Primary completion: Sep 30, 2013 Completion: Nov 30, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Neurotoxicity and Pain, this trial is completed. The trial is conducted by Gary Morrow and has accumulated 8 data snapshots since 2007. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Dec 2021 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — Dec 2021 [monthly]

Completed PHASE3

▶ Show 3 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Oct 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Gary Morrow
National Cancer Institute (NCI)

Data source: University of Rochester

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Chicago, United States , Decatur, United States , East Syracuse, United States , Evanston, United States , Grand Rapids, United States , Greenville, United States , Honolulu, United States , Las Vegas, United States , Manhasset, United States , Marshfield, United States and 7 more locations