Completed PHASE3 INTERVENTIONAL 4-arm NCT00494507

Hyper- and Hypokalemic Periodic Paralysis Study (HYP-HOP)

Dichlorphenamide vs. Placebo for Periodic Paralysis

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Conditions Hyperkalemic Periodic Paralysis Hypokalemic Periodic Paralysis

Interventions Dichlorphenamide (double-blind) Dichlorphenamide (open-label) Placebo (double-blind)

Updated 9 times since 2017 Last updated: May 15, 2017 Started: Jun 30, 2007 Primary completion: Apr 30, 2013 Completion: May 31, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00494507, this PHASE3 trial focuses on Hyperkalemic Periodic Paralysis and Hypokalemic Periodic Paralysis and remains completed. Sponsored by National Institute of Neurological Disorders and Stroke (NINDS), it has been updated 9 times since 2007, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Dec 2021 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — Dec 2021 [monthly]

Completed PHASE3

▶ Show 4 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE3
Jul 2017 — Jun 2018 [monthly]

Completed PHASE3
Feb 2017 — Jul 2017 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Jun 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Institute of Neurological Disorders and Stroke (NINDS)
University of Rochester

Data source: University of Rochester

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Boston, United States , Columbus, United States , Dallas, United States , Kansas City, United States , London, United Kingdom , Los Angeles, United States , New York, United States , Rochester, United States , San Donato, Italy , San Francisco, United States and 1 more location