deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT00508989

Niacin to Improve Blood Flow in People With Sickle Cell Disease

Niacin Therapy to Improve Endothelial Function in Sickle Cell Disease

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Conditions Sickle Cell Disease
Interventions Acetylcholine L-NMMA Niacin-ER Placebo
Updated 13 times since 2017 Last updated: Sep 3, 2020 Started: Jul 24, 2007 Primary completion: Dec 31, 2010 Completion: Dec 24, 2015
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Sickle Cell Disease and is currently completed. National Heart, Lung, and Blood Institute (NHLBI) leads this study, which shows 13 recorded versions since 2007 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Mar 2018 · 10 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~May 2019 · 9 months · monthly snapshot~May 2019 – ~Oct 2020 · 17 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2022 · 15 months · monthly snapshot~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

13 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Apr 2022 — Jul 2024 [monthly]

    Completed PHASE2

  5. Jan 2021 — Apr 2022 [monthly]

    Completed PHASE2

▶ Show 8 earlier versions

  1. Oct 2020 — Jan 2021 [monthly]

    Completed PHASE2

  2. May 2019 — Oct 2020 [monthly]

    Completed PHASE2

  3. Aug 2018 — May 2019 [monthly]

    Completed PHASE2

  4. Jun 2018 — Aug 2018 [monthly]

    Completed PHASE2

  5. Mar 2018 — Jun 2018 [monthly]

    Completed PHASE2

  6. May 2017 — Mar 2018 [monthly]

    Completed PHASE2

  7. Feb 2017 — May 2017 [monthly]

    Completed PHASE2

  8. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE2

    First recorded

Jul 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Heart, Lung, and Blood Institute (NHLBI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations