deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT00558220

R-MegaCHOP-ESHAP-BEAM in Patients With High-Risk Aggressive B-Cell Lymphomas (R-MCEB)

Phase II Study of Intensive Induction (R-MegaCHOP/ESHAP)Followed By Intensive Consolidation (BEAM) In Treatment Of High-Risk Aggressive B-Cell Lymphomas

Sponsor: Czech Lymphoma Study Group

Conditions Diffuse Large B-Cell Lymphoma. Follicular Lymphoma Grade III Primary Mediastinal B-Cell Lymphoma
Interventions Consolidation treatment part 1: HD-chemotherapy with ASCT Consolidation treatment part 2: Radiotherapy Induction treatment part 1 Induction treatment part 2 with PBPC collection Induction treatment part 3 immunotherapy
Updated 6 times since 2017 Last updated: Nov 10, 2007 Started: May 31, 2002 Completion: Oct 31, 2006
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Diffuse Large B-Cell Lymphoma. and Follicular Lymphoma Grade III, this trial is completed. The trial is conducted by Czech Lymphoma Study Group and has accumulated 6 data snapshots since 2002. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshotCompleted~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 10 months · monthly snapshotCompleted

Change History

6 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE2

  5. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE2

▶ Show 1 earlier version

  1. Jan 2017 — Jun 2018 [monthly]

    Completed PHASE2

    First recorded

May 2002

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Czech Lymphoma Study Group
  • Hoffmann-La Roche
  • Ministry of Health, Czech Republic
Data source: Czech Lymphoma Study Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations