Terminated PHASE3 INTERVENTIONAL NCT00566644

Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome

Prevention of Endometrial Tumors (POET)

Sponsor: St George's, University of London

Conditions Endometrial Cancer Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)

Interventions levonorgestrel-releasing intrauterine system observation questionnaire administration

Updated 6 times since 2017 Last updated: Jul 9, 2013 Started: Jul 31, 2007 Primary completion: Oct 31, 2008 Completion: Aug 31, 2009

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Withdrawn due to poor accrual

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A PHASE3 clinical study on Endometrial Cancer and Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2), this trial is terminated or withdrawn. The trial is conducted by St George's, University of London and has accumulated 6 data snapshots since 2007. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

6 versions recorded

Sep 2025 — Present [monthly]

Terminated PHASE3
Sep 2024 — Sep 2025 [monthly]

Terminated PHASE3
Jul 2024 — Sep 2024 [monthly]

Terminated PHASE3
Jan 2021 — Jul 2024 [monthly]

Terminated PHASE3
Jun 2018 — Jan 2021 [monthly]

Terminated PHASE3

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Terminated PHASE3

First recorded

Jul 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

St George's, University of London

Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United Kingdom , Bangor, United Kingdom , Basildon, United Kingdom , Belfast, United Kingdom , Birmingham, United Kingdom , Cambridge, United Kingdom , Cardiff, United Kingdom , Cheltenham, United Kingdom , Exeter, United Kingdom , Gateshead-Tyne and Wear, United Kingdom and 7 more locations