Completed NA INTERVENTIONAL 2-arm NCT00653432

Safety and Effectiveness of Monovisc® Injection for Osteoarthritis of the Knee

A Randomized, Double-Blind, Placebo Controlled, Multi-Center Study of a Single Injection Cross-Linked Sodium Hyaluronate to Provide Symptomatic Relief of Osteoarthritis of the Knee

Sponsor: Anika Therapeutics, Inc.

Conditions Osteoarthritis

Interventions Monovisc® Saline

Updated 9 times since 2017 Last updated: Jun 21, 2023 Started: Jan 31, 2008 Primary completion: Dec 31, 2009 Completion: Feb 28, 2010

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00653432, this NA trial focuses on Osteoarthritis and remains completed. Sponsored by Anika Therapeutics, Inc., it has been updated 9 times since 2008, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed NA
Sep 2024 — Sep 2025 [monthly]

Completed NA
Jul 2024 — Sep 2024 [monthly]

Completed NA
Aug 2023 — Jul 2024 [monthly]

Completed NA
Jan 2021 — Aug 2023 [monthly]

Completed NA

▶ Show 4 earlier versions

Oct 2020 — Jan 2021 [monthly]

Completed NA
Jun 2018 — Oct 2020 [monthly]

Completed NA
Feb 2017 — Jun 2018 [monthly]

Completed NA
Jan 2017 — Feb 2017 [monthly]

Completed NA

First recorded

Jan 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Anika Therapeutics, Inc.

Data source: Anika Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Bay City, United States , Boise, United States , Boulder, United States , Burbank, United States , Chicago, United States , Cos Cob, United States , Cumming, United States , Duncansville, United States , Englewood, United States and 21 more locations