Completed PHASE3 INTERVENTIONAL 2-arm NCT00707265

rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study (CRM)

A Prospective, Randomized Clinical Investigation of rhBMP-2 and Compression Resistant Matrix With the CD HORIZON® Spinal System for Posterolateral Lumbar Fusion in Patients With Symptomatic Degenerative Disc Disease

Sponsor: Medtronic Spinal and Biologics

Conditions Degenerative Disc Disease

Interventions Autograft/CD HORIZON® Spinal System rhBMP-2/CRM/CD HORIZON® Spinal System

Updated 8 times since 2017 Last updated: May 9, 2023 Started: Mar 31, 2002 Primary completion: May 31, 2005 Completion: Feb 28, 2010

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Degenerative Disc Disease and is currently completed. Medtronic Spinal and Biologics leads this study, which shows 8 recorded versions since 2002 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jun 2023 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — Jun 2023 [monthly]

Completed PHASE3

▶ Show 3 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Mar 2002

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Medtronic Spinal and Biologics

Data source: Medtronic Spinal and Biologics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Carmel, United States , Charlottesville, United States , Columbus, United States , Durham, United States , Fort Worth, United States , Hoffman Estates, United States , Iowa City, United States , Johnson City, United States , Louisville, United States and 18 more locations