deltatrials
Completed PHASE1 INTERVENTIONAL NCT00727233

Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

Phase I Trial of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, Nexavar) in Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

Sponsor: National Cancer Institute (NCI)

Conditions Neurofibromatosis Type I Plexiform Neurofibroma
Interventions Bony Toxicity Nexavar (BAY 43-9006) (Sorafenib) Pharmacodynamics QOL assessment, Neuropsychological Radiographic Evaluation Toxicity, Pharmacokinetics
Updated 26 times since 2017 Last updated: Dec 11, 2019 Started: Jul 8, 2008 Primary completion: Jun 16, 2011 Completion: Jun 16, 2011
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Neurofibromatosis Type I and Plexiform Neurofibroma and is currently completed. National Cancer Institute (NCI) leads this study, which shows 26 recorded versions since 2008 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2018 · 15 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

26 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. Jan 2020 — Jan 2021 [monthly]

    Completed PHASE1

  5. Dec 2019 — Jan 2020 [monthly]

    Completed PHASE1

▶ Show 21 earlier versions

  1. Nov 2019 — Dec 2019 [monthly]

    Completed PHASE1

  2. Oct 2019 — Nov 2019 [monthly]

    Completed PHASE1

  3. Sep 2019 — Oct 2019 [monthly]

    Completed PHASE1

  4. Aug 2019 — Sep 2019 [monthly]

    Completed PHASE1

  5. Jul 2019 — Aug 2019 [monthly]

    Completed PHASE1

  6. Jun 2019 — Jul 2019 [monthly]

    Completed PHASE1

  7. May 2019 — Jun 2019 [monthly]

    Completed PHASE1

  8. Apr 2019 — May 2019 [monthly]

    Completed PHASE1

  9. Mar 2019 — Apr 2019 [monthly]

    Completed PHASE1

  10. Feb 2019 — Mar 2019 [monthly]

    Completed PHASE1

  11. Jan 2019 — Feb 2019 [monthly]

    Completed PHASE1

  12. Dec 2018 — Jan 2019 [monthly]

    Completed PHASE1

  13. Nov 2018 — Dec 2018 [monthly]

    Completed PHASE1

  14. Oct 2018 — Nov 2018 [monthly]

    Completed PHASE1

  15. Sep 2018 — Oct 2018 [monthly]

    Completed PHASE1

  16. Aug 2018 — Sep 2018 [monthly]

    Completed PHASE1

  17. Jul 2018 — Aug 2018 [monthly]

    Completed PHASE1

  18. Jun 2018 — Jul 2018 [monthly]

    Completed PHASE1

  19. May 2018 — Jun 2018 [monthly]

    Completed PHASE1

  20. Feb 2017 — May 2018 [monthly]

    Completed PHASE1

  21. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE1

    First recorded

Jul 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations