Completed PHASE1 INTERVENTIONAL 1-arm NCT00748059

The Pathophysiology of Orthostatic Hypotension

Sponsor: Vanderbilt University Medical Center

Conditions Autonomic Nervous System Diseases Dopamine Beta-Hydroxylase Deficiency Orthostatic Hypotension Orthostatic Intolerance

Interventions Bicycle Exercise Test BodPod Brain function studies Eye exam Metabolic chamber Microneurography Pain response testing QSweat Sleep study Standing or upright tilt clonidine,yohimbine,metoclopramide,alpha-methyldopa neck cuff stimulation phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine

Updated 12 times since 2017 Last updated: May 7, 2021 Started: Dec 31, 1996 Primary completion: Dec 31, 2020 Completion: Dec 31, 2020

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Autonomic Nervous System Diseases and Dopamine Beta-Hydroxylase Deficiency and is currently completed. Vanderbilt University Medical Center leads this study, which shows 12 recorded versions since 1996 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

12 versions recorded

Sep 2024 — Present [monthly]

Completed PHASE1
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1
Jun 2021 — Jul 2024 [monthly]

Completed PHASE1

Status: Active Not Recruiting → Completed
Feb 2021 — Jun 2021 [monthly]

Active Not Recruiting PHASE1
Jan 2021 — Feb 2021 [monthly]

Active Not Recruiting PHASE1

▶ Show 7 earlier versions

Mar 2020 — Jan 2021 [monthly]

Active Not Recruiting PHASE1
Feb 2019 — Mar 2020 [monthly]

Active Not Recruiting PHASE1
Jun 2018 — Feb 2019 [monthly]

Active Not Recruiting PHASE1
Jul 2017 — Jun 2018 [monthly]

Active Not Recruiting PHASE1
May 2017 — Jul 2017 [monthly]

Active Not Recruiting PHASE1
Feb 2017 — May 2017 [monthly]

Active Not Recruiting PHASE1
Jan 2017 — Feb 2017 [monthly]

Active Not Recruiting PHASE1

First recorded

Dec 1996

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Vanderbilt University Medical Center

Data source: Vanderbilt University Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Nashville, United States