deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT00788125

Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors

Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial

Sponsor: City of Hope Medical Center

Conditions Brain and Central Nervous System Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor Kidney Cancer Liver Cancer Lymphoma Neuroblastoma Ovarian Cancer Sarcoma Testicular Germ Cell Tumor Unspecified Childhood Solid Tumor, Protocol Specific
Interventions carboplatin dasatinib etoposide phosphate ifosfamide immunohistochemistry staining method laboratory biomarker analysis microarray analysis radiation therapy therapeutic conventional surgery western blotting
Updated 15 times since 2017 Last updated: Jul 11, 2023 Started: Sep 3, 2008 Primary completion: Apr 30, 2010 Completion: Jul 30, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Terminated early due a shift in resources after lackluster performance of the drug.

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A PHASE1/PHASE2 clinical study on Brain and Central Nervous System Tumors and Childhood Germ Cell Tumor, this trial is terminated or withdrawn. The trial is conducted by City of Hope Medical Center and has accumulated 15 data snapshots since 2008. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Sep 2017 · 7 months · monthly snapshot~Sep 2017 – ~Mar 2018 · 6 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Sep 2019 · 12 months · monthly snapshot~Sep 2019 – ~Mar 2020 · 6 months · monthly snapshot~Mar 2020 – ~Jan 2021 · 10 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~May 2022 · 13 months · monthly snapshot~May 2022 – ~Apr 2023 · 11 months · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

15 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Aug 2023 — Jul 2024 [monthly]

    Terminated PHASE1_PHASE2

    Status: Active Not Recruiting → Terminated

  4. Apr 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Terminated → Active Not Recruiting

  5. May 2022 — Apr 2023 [monthly]

    Terminated PHASE1_PHASE2

    Status: Active Not Recruiting → Terminated

▶ Show 10 earlier versions

  1. Apr 2021 — May 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Mar 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Sep 2019 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Sep 2018 — Sep 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Jun 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Mar 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Sep 2017 — Mar 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. Feb 2017 — Sep 2017 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    First recorded

Sep 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • City of Hope Medical Center
  • National Cancer Institute (NCI)
Data source: City of Hope Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations