Completed PHASE2/PHASE3 INTERVENTIONAL 2-arm NCT00795756

Intrathecal DepoCyte and Lineage-targeted Minimal Residual Disease-oriented Therapy of Acute Lymphoblastic Leukemia

A Randomized Study on CNS Prophylaxis With Liposome-Encapsulated Cytarabine in Association With a Lineage-Targeted and MRD-Oriented Postremission Strategy in Adult ALL

Sponsor: Northern Italy Leukemia Group

Conditions Acute Lymphoblastic Leukemia

Interventions Triple intrathecal therapy (TIT) liposome-encapsulated cytarabine (DepoCyte)

Updated 6 times since 2017 Last updated: Oct 21, 2014 Started: Jan 31, 2008 Primary completion: Oct 31, 2013 Completion: Oct 31, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2/PHASE3 trial investigates Acute Lymphoblastic Leukemia and is currently completed. Northern Italy Leukemia Group leads this study, which shows 6 recorded versions since 2008 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

6 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2/PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2/PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2/PHASE3

Phase: PHASE2_PHASE3 → PHASE2/PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2_PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE2_PHASE3

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Completed PHASE2_PHASE3

First recorded

Jan 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Northern Italy Leukemia Group

Data source: Northern Italy Leukemia Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Alessandria, Italy , Bergamo, Italy , Bolzano, Italy , Brescia, Italy , Cagliari, Italy , Cremona, Italy , Cuneo, Italy , Florence, Italy , Milan, Italy , Monza, Italy and 5 more locations