deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT00813423

Sunitinib Malate and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy

Autophagic Modulation With Anti-angiogenic Therapy in Patients With Advanced Malignancies: A Phase I Trial of Sunitinib and Hydroxychloroquine

Sponsor: National Cancer Institute (NCI)

Conditions Adult Solid Neoplasm
Interventions Hydroxychloroquine Laboratory Biomarker Analysis Pharmacological Study Sunitinib Malate
Updated 29 times since 2017 Last updated: Aug 1, 2023 Started: Feb 19, 2010 Primary completion: Jul 18, 2023 Completion: Jul 18, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Adult Solid Neoplasm and is currently completed. National Cancer Institute (NCI) leads this study, which shows 29 recorded versions since 2010 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Jun 2018 · 12 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Jan 2019 · 5 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Oct 2020 · 3 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~May 2022 · 8 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Jun 2023 · 3 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

29 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Sep 2023 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  4. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

▶ Show 24 earlier versions

  1. Sep 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  2. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  3. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2021 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  5. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  6. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1

  8. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  9. Jul 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1

  10. May 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1

  11. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1

  12. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE1

  13. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1

  14. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

  15. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1

  16. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE1

  17. Jul 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE1

  18. Mar 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1

  19. Jan 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1

  20. Aug 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE1

  21. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE1

  22. Jun 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

  23. Feb 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE1

  24. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Feb 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations