deltatrials
Completed PHASE3 INTERVENTIONAL 4-arm NCT00933231

Comparison of Standard Versus Low Dose Advagraf® With or Without Angiotensin-converting Enzyme Inhibitor (ACEi)/Angiotensin Receptor Blocker (ARB) on Histology and Function of Renal Allografts

A Comparison of Effects of Standard Dose vs. Low Dose Advagraf® With IL-2 Receptor Antibody Induction, MMF and Steroids, With or Without ACEi/ARB - Based Antihypertensive Therapy on Renal Allograft Histology, Function, and Immune Response

Sponsor: Astellas Pharma Canada, Inc.

Updated 12 times since 2017 Last updated: Oct 30, 2024 Started: Aug 17, 2009 Primary completion: May 11, 2015 Completion: Apr 3, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Kidney Transplantation and is currently completed. Astellas Pharma Canada, Inc. leads this study, which shows 12 recorded versions since 2009 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotActive Not Recruiting~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshotActive Not Recruiting~Aug 2017 – ~Nov 2017 · 3 months · monthly snapshotActive Not Recruiting~Nov 2017 – ~Jun 2018 · 7 months · monthly snapshotActive Not Recruiting~Jun 2018 – ~May 2019 · 11 months · monthly snapshotCompleted~May 2019 – ~Jan 2021 · 20 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshotCompleted~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshotCompleted~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshotCompleted~Sep 2025 – present · 10 months · monthly snapshotCompleted

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Dec 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Nov 2024 — Dec 2024 [monthly]

    Completed PHASE3

  4. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

Show 7 earlier versions
  1. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE3

  2. May 2019 — Jan 2021 [monthly]

    Completed PHASE3

  3. Jun 2018 — May 2019 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  4. Nov 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  5. Aug 2017 — Nov 2017 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Aug 2009

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Astellas Pharma Canada, Inc.
  • Astellas Pharma Inc
Data source: Astellas Pharma Inc

For direct contact, visit the study record on ClinicalTrials.gov .