Completed PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT00945542

The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study) (TRFL)

Formula-driven vs Laboratory-guided Transfusion Practices in Bleeding Trauma Patients: A Feasibility Randomized Controlled Study

Sponsor: Canadian Blood Services

Conditions Hemorrhagic Shock Trauma Coagulopathy

Interventions Massive transfusion protocol Standard of care

Updated 6 times since 2017 Last updated: Dec 1, 2011 Started: Jul 31, 2009 Primary completion: Dec 31, 2011 Completion: Dec 31, 2011

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00945542, this PHASE1/PHASE2 trial focuses on Hemorrhagic Shock and Trauma Coagulopathy and remains completed. Sponsored by Canadian Blood Services, it has been updated 6 times since 2009, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

6 versions recorded

Jan 2026 — Present [monthly]

Completed PHASE1/PHASE2
Sep 2024 — Jan 2026 [monthly]

Completed PHASE1/PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1/PHASE2

Phase: PHASE1_PHASE2 → PHASE1/PHASE2
Jan 2021 — Jul 2024 [monthly]

Completed PHASE1_PHASE2
Jun 2018 — Jan 2021 [monthly]

Completed PHASE1_PHASE2

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Completed PHASE1_PHASE2

First recorded

Jul 2009

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Canadian Blood Services
Canadian Department of National Defence
National Blood Foundation
Sunnybrook Health Sciences Centre

Data source: Sunnybrook Health Sciences Centre

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Toronto, Canada