deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT01143545

Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas

Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib as Adjuvant Therapy for Lung and Esophageal Cancers, Thymic Neoplasms, Thoracic Sarcomas, and Malignant Pleural Mesotheliomas

Sponsor: National Cancer Institute (NCI)

Conditions Esophageal Cancer Lung Cancer Malignant Pleural Mesothelioma Sarcoma Thymic Carcinoma
Interventions Allogeneic Tumor Cell Vaccine (K562) Celecoxib cyclophosphamide
Updated 25 times since 2017 Last updated: Mar 2, 2020 Started: Dec 7, 2010 Primary completion: Feb 9, 2015 Completion: Feb 26, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Closed accrual due to unpromising results and the opening of study 14C0053 targeting the same population.

Other terminated trials from National Cancer Institute (NCI)

See all terminations from National Cancer Institute (NCI)

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Listed as NCT01143545, this PHASE1 trial focuses on Esophageal Cancer and Lung Cancer and remains terminated or withdrawn. Sponsored by National Cancer Institute (NCI), it has been updated 25 times since 2010, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Nov 2020 · 7 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  3. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE1

  4. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE1

  5. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE1

▶ Show 20 earlier versions

  1. Apr 2020 — Nov 2020 [monthly]

    Terminated PHASE1

    Status: Completed → Terminated

  2. Feb 2020 — Apr 2020 [monthly]

    Completed PHASE1

  3. Jan 2020 — Feb 2020 [monthly]

    Completed PHASE1

  4. Dec 2019 — Jan 2020 [monthly]

    Completed PHASE1

  5. Oct 2019 — Dec 2019 [monthly]

    Completed PHASE1

  6. Jul 2019 — Oct 2019 [monthly]

    Completed PHASE1

  7. Jun 2019 — Jul 2019 [monthly]

    Completed PHASE1

  8. May 2019 — Jun 2019 [monthly]

    Completed PHASE1

  9. Apr 2019 — May 2019 [monthly]

    Completed PHASE1

  10. Mar 2019 — Apr 2019 [monthly]

    Completed PHASE1

  11. Feb 2019 — Mar 2019 [monthly]

    Completed PHASE1

  12. Jan 2019 — Feb 2019 [monthly]

    Completed PHASE1

  13. Dec 2018 — Jan 2019 [monthly]

    Completed PHASE1

  14. Nov 2018 — Dec 2018 [monthly]

    Completed PHASE1

  15. Oct 2018 — Nov 2018 [monthly]

    Completed PHASE1

  16. Sep 2018 — Oct 2018 [monthly]

    Completed PHASE1

  17. Aug 2018 — Sep 2018 [monthly]

    Completed PHASE1

  18. Jun 2018 — Aug 2018 [monthly]

    Completed PHASE1

  19. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE1

  20. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE1

    First recorded

Dec 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations