Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients
Observation of the Abnormal Potential From the Offending Vessel to the Facial Muscles of Hemifacial Spasm Patients
Sponsor: Shanghai Jiao Tong University School of Medicine
This observational or N/A phase trial investigates Hemifacial Spasm and is currently ongoing. Shanghai Jiao Tong University School of Medicine leads this study, which shows 8 recorded versions since 2011 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Study Description(click to expand)It's hypothesized that at the location where the facial nerve is compressed by an artery, ephaptic cross-transmission takes place between the nude facial nerve fibers and the sympathetic nerve fibers on the arterial surface. Thus action potentials could spread indirectly from one facial nerve fiber to several other facial nerve fibers (via the "bridge" of sympathetic fibers), or directly from the sympathetic fibers to facial nerve fibers. The investigators assume this is the electrophysiological basis of hemifacial spasm and its characteristic sign abnormal muscle response (AMR). If an abnormal potential from the offending artery to the facial muscles similar to AMR can be recorded, the hypothesis will be verified.
It's hypothesized that at the location where the facial nerve is compressed by an artery, ephaptic cross-transmission takes place between the nude facial nerve fibers and the sympathetic nerve fibers on the arterial surface. Thus action potentials could spread indirectly from one facial nerve fiber to several other facial nerve fibers (via the "bridge" of sympathetic fibers), or directly from the sympathetic fibers to facial nerve fibers. The investigators assume this is the electrophysiological basis of hemifacial spasm and its characteristic sign abnormal muscle response (AMR). If an abnormal potential from the offending artery to the facial muscles similar to AMR can be recorded, the hypothesis will be verified.
Status Flow
Change History
8 versions recorded-
Jan 2026 — Present [monthly]
Unknown
-
Sep 2024 — Present [monthly]
Unknown
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Jul 2024 — Sep 2024 [monthly]
Unknown
Status: Unknown Status → Unknown
-
Jan 2021 — Jul 2024 [monthly]
Unknown Status
-
Jun 2018 — Jan 2021 [monthly]
Unknown Status
▶ Show 3 earlier versions
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Apr 2018 — Jun 2018 [monthly]
Unknown Status
Phase: NA → None
-
Feb 2017 — Apr 2018 [monthly]
Unknown Status NA
Status: Enrolling By Invitation → Unknown Status
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Jan 2017 — Feb 2017 [monthly]
Enrolling By Invitation NA
First recorded
Jan 2011
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Shanghai Jiao Tong University School of Medicine
For direct contact, visit the study record on ClinicalTrials.gov .