deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT01273168

Endoxifen in Adults With Hormone Receptor Positive Solid Tumors

Phase I Trial of Z-Endoxifen in Adults With Refractory Hormone Receptor-Positive Breast Cancer, Desmoid Tumors, Gynecologic Tumors, or Other Hormone Receptor-Positive Solid Tumors

Sponsor: National Cancer Institute (NCI)

Interventions Z-Endoxifen
Updated 73 times since 2017 Last updated: Dec 19, 2025 Started: Mar 1, 2011 Primary completion: Jun 1, 2020 Completion: Dec 19, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Desmoid and Gynecologic, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 73 data snapshots since 2011. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Feb 2018 · 12 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Dec 2018 · 4 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Oct 2019 · 4 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

73 versions recorded
  1. Jan 2026 — Present [monthly]

    Completed PHASE1

    Status: Active Not RecruitingCompleted

  2. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

Show 68 earlier versions
  1. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  3. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

  6. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  7. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  8. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

  9. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

  10. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  11. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  12. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  13. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  14. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  15. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  16. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  17. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  18. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  19. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  20. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  21. Sep 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  22. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  23. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  24. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  25. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  26. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  27. Feb 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  28. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  29. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  30. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  31. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

  32. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  33. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  34. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  35. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  36. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  37. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  38. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  39. Nov 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  40. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  41. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1

  42. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  43. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1

  44. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1

  45. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1

  46. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1

  47. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1

  48. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  49. Oct 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1

  50. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1

  51. Jul 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE1

  52. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1

  53. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

  54. Mar 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1

  55. Jan 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1

  56. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1

  57. Oct 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE1

  58. Jun 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE1

  59. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE1

  60. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE1

  61. Jan 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1

  62. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE1

  63. Aug 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE1

  64. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE1

  65. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE1

  66. Feb 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  67. Feb 2017 — Feb 2018 [monthly]

    Recruiting PHASE1

  68. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Mar 2011

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations