deltatrials
Terminated NA INTERVENTIONAL 2-arm NCT01329172

Nasal Mucin Oral Supplementation Treatment Respiratory Inflammation Using PUFA in Cystic Fibrosis (CF) Patients (NOSTRIL)

Impact of Polyunsaturated Fatty Acids n-3 on Nasal Mucins Expression in Cystic Fibrosis Patients

Sponsor: University Hospital, Lille

Conditions Cystic Fibrosis Dietary Modification
Interventions placebo polyunsaturated fatty acids n-3
Updated 9 times since 2017 Last updated: Dec 21, 2017 Started: Sep 20, 2010 Primary completion: Oct 31, 2017 Completion: Oct 31, 2017
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

This trial was terminated. No reason was provided.

A NA clinical study on Cystic Fibrosis and Dietary Modification, this trial is terminated or withdrawn. The trial is conducted by University Hospital, Lille and has accumulated 9 data snapshots since 2010. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Study Description(click to expand)

Primary Outcome Measure : Mucin MUC5B (mRNA level) in native airway epithelial cells obtained by nasal brushing Secondary Outcome Measures : Mucin MUC1, MUC2, MUC4, MUC5AC, MUC7 (mRNA level) in native airway epithelial cells obtained by nasal brushing. Lund-Kennedy score TNF-alpha, IL-6, IL-8 in plasma

Primary Outcome Measure : Mucin MUC5B (mRNA level) in native airway epithelial cells obtained by nasal brushing

Secondary Outcome Measures : Mucin MUC1, MUC2, MUC4, MUC5AC, MUC7 (mRNA level) in native airway epithelial cells obtained by nasal brushing.

Lund-Kennedy score TNF-alpha, IL-6, IL-8 in plasma

Status Flow

~Jan 2017 – ~Jun 2017 · 5 months · monthly snapshotRecruiting~Jun 2017 – ~Jan 2018 · 7 months · monthly snapshotRecruiting~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshotTerminated~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotTerminated~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotTerminated~Sep 2025 – present · 7 months · monthly snapshotTerminated~Jan 2026 – present · 3 months · monthly snapshotTerminated

Change History

9 versions recorded

  1. Jan 2026 — Present [monthly]

    Terminated NA

  2. Sep 2025 — Present [monthly]

    Terminated NA

  3. Sep 2024 — Sep 2025 [monthly]

    Terminated NA

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated NA

  5. Jan 2021 — Jul 2024 [monthly]

    Terminated NA

▶ Show 4 earlier versions

  1. Jun 2018 — Jan 2021 [monthly]

    Terminated NA

  2. Jan 2018 — Jun 2018 [monthly]

    Terminated NA

    Status: Recruiting → Terminated

  3. Jun 2017 — Jan 2018 [monthly]

    Recruiting NA

  4. Jan 2017 — Jun 2017 [monthly]

    Recruiting NA

    First recorded

Sep 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University Hospital, Lille
Data source: University Hospital, Lille

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations