Completed PHASE3 INTERVENTIONAL 2-arm NCT01370733

Synchronized Transcranial Magnetic Stimulation (sTMS) in Major Depressive Disorder (NEST-MDD)

Evaluation of Low Emission NeoSync EEG Synchronized TMS Technology for the Treatment of Major Depressive Disorder: A Multicenter, Randomized, Double-Blind, Sham-Controlled, Trial

Sponsor: Wave Neuroscience

Conditions Major Depressive Disorder

Interventions NEST-1 (NeoSync EEG Synchronized TMS) SHAM

Updated 8 times since 2017 Last updated: Oct 5, 2015 Started: May 31, 2012 Primary completion: Aug 31, 2013 Completion: Sep 30, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Major Depressive Disorder and is currently completed. Wave Neuroscience leads this study, which shows 8 recorded versions since 2012 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Oct 2020 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 3 earlier versions

Jun 2018 — Oct 2020 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

May 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Wave Neuroscience

Data source: Wave Neuroscience

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Charleston, United States , Cherry Hill, United States , Chicago, United States , Dallas, United States , Durham, United States , Hartford, United States , Lake Jackson, United States , Los Angeles, United States , New York, United States and 8 more locations