Completed PHASE2 INTERVENTIONAL 4-arm NCT01414153

Efficacy and Safety Study of iSONEP With & Without Lucentis/Avastin/Eylea to Treat Wet AMD (Nexus)

Phase 2a, Multicenter, Masked, Randomized, Comparator Controlled Study Evaluating iSONEP™ as Monotherapy or Adjunctive Therapy to Lucentis/Avastin/Eylea Versus Lucentis/Avastin/Eylea Alone for Treatment of Subjects With Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)

Sponsor: Lpath, Inc.

Conditions Exudative Age-related Macular Degeneration

Interventions 0.5 mg Lucentis or 1.25 mg Avastin or 2 mg Eylea 0.5 mg iSONEP 4.0 mg iSONEP sham injection

Updated 9 times since 2017 Last updated: Aug 22, 2016 Started: Aug 31, 2012 Primary completion: May 31, 2015 Completion: Jun 30, 2015

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Exudative Age-related Macular Degeneration, this trial is completed. The trial is conducted by Lpath, Inc. and has accumulated 9 data snapshots since 2012. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2023 — Jul 2024 [monthly]

Completed PHASE2
Dec 2022 — Jan 2023 [monthly]

Completed PHASE2

▶ Show 4 earlier versions

Jan 2021 — Dec 2022 [monthly]

Completed PHASE2
Jun 2018 — Jan 2021 [monthly]

Completed PHASE2
Feb 2017 — Jun 2018 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

Aug 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Lpath, Inc.

Data source: Lpath, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abilene, United States , Ashland, United States , Austin, United States , Beverly Hills, United States , Boston, United States , Boynton Beach, United States , Campbell, United States , Charlotte, United States , Chevy Chase, United States , Dallas, United States and 31 more locations