deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT01466686

Low Dose Radiation Therapy for Glioblastoma Multiforme

A Phase II Trial of Low Dose Fractionated Radiation Therapy as a Chemo-Potentiator of Salvage Temozolomide for Recurrent Anaplastic Astrocytoma and Glioblastoma Multiforme

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Conditions High Grade Glioma
Interventions Low Dose Fractionated Radiation Therapy (LDFRT) Temozolomide
Updated 14 times since 2017 Last updated: Jun 14, 2023 Started: Sep 30, 2012 Primary completion: Dec 31, 2021 Completion: Dec 31, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on High Grade Glioma, this trial is completed. The trial is conducted by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and has accumulated 14 data snapshots since 2012. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Oct 2017 · 8 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Jan 2020 · 13 months · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshot~Nov 2021 – ~Jul 2022 · 8 months · monthly snapshot~Jul 2022 – ~Mar 2023 · 8 months · monthly snapshot~Mar 2023 – ~Aug 2023 · 5 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

14 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Aug 2023 — Jul 2024 [monthly]

    Completed PHASE2

  5. Mar 2023 — Aug 2023 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

▶ Show 9 earlier versions

  1. Jul 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Nov 2021 — Jul 2022 [monthly]

    Recruiting PHASE2

  3. Jan 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  4. Jan 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  5. Dec 2018 — Jan 2020 [monthly]

    Recruiting PHASE2

  6. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  7. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  8. Feb 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  9. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Data source: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations