Metformin in Children With Relapsed or Refractory Solid Tumors
A Phase I Trial of Dose Escalation of Metformin in Combination With Vincristine, Irinotecan, and Temozolomide in Children With Relapsed or Refractory Solid Tumors
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Listed as NCT01528046, this PHASE1 trial focuses on Primary Brain Tumors and Solid Tumors and remains completed. Sponsored by H. Lee Moffitt Cancer Center and Research Institute, it has been updated 27 times since 2012, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
27 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE1
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Sep 2024 — Sep 2025 [monthly]
Completed PHASE1
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE1
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Feb 2023 — Jul 2024 [monthly]
Completed PHASE1
Status: Active Not Recruiting → Completed
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Sep 2022 — Feb 2023 [monthly]
Active Not Recruiting PHASE1
▶ Show 22 earlier versions
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May 2022 — Sep 2022 [monthly]
Active Not Recruiting PHASE1
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Apr 2022 — May 2022 [monthly]
Active Not Recruiting PHASE1
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Feb 2022 — Apr 2022 [monthly]
Active Not Recruiting PHASE1
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Nov 2021 — Feb 2022 [monthly]
Active Not Recruiting PHASE1
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Jun 2021 — Nov 2021 [monthly]
Active Not Recruiting PHASE1
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Jan 2021 — Jun 2021 [monthly]
Active Not Recruiting PHASE1
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Aug 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE1
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May 2020 — Aug 2020 [monthly]
Active Not Recruiting PHASE1
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Mar 2020 — May 2020 [monthly]
Active Not Recruiting PHASE1
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Jan 2020 — Mar 2020 [monthly]
Active Not Recruiting PHASE1
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Dec 2019 — Jan 2020 [monthly]
Active Not Recruiting PHASE1
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Oct 2019 — Dec 2019 [monthly]
Active Not Recruiting PHASE1
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Aug 2019 — Oct 2019 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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May 2019 — Aug 2019 [monthly]
Recruiting PHASE1
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Dec 2018 — May 2019 [monthly]
Recruiting PHASE1
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Jul 2018 — Dec 2018 [monthly]
Recruiting PHASE1
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Jun 2018 — Jul 2018 [monthly]
Recruiting PHASE1
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Feb 2018 — Jun 2018 [monthly]
Recruiting PHASE1
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Aug 2017 — Feb 2018 [monthly]
Recruiting PHASE1
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Jun 2017 — Aug 2017 [monthly]
Recruiting PHASE1
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Feb 2017 — Jun 2017 [monthly]
Recruiting PHASE1
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Sep 2012
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- H. Lee Moffitt Cancer Center and Research Institute
- Pediatric Cancer Foundation
For direct contact, visit the study record on ClinicalTrials.gov .