deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT01597440

Long-term Outcome of N-Carbamylglutamate Treatment in Propionic Acidemia and Methylmalonic Acidemia

Sponsor: Boston Children's Hospital

Conditions Methylmalonic Acidemia Propionic Acidemia
Interventions N-carbamylglutamate Standard of Care
Updated 12 times since 2017 Last updated: Mar 15, 2017 Started: Sep 30, 2012 Primary completion: Feb 28, 2015 Completion: Feb 28, 2015
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

insufficient enrollment

Other terminated trials from Boston Children's Hospital

See all terminations from Boston Children's Hospital

This PHASE2 trial investigates Methylmalonic Acidemia and Propionic Acidemia and is currently terminated or withdrawn. Boston Children's Hospital leads this study, which shows 12 recorded versions since 2012 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotTerminated~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshotTerminated~Jun 2017 – ~Jun 2018 · 12 months · monthly snapshotTerminated~Jun 2018 – ~Mar 2020 · 21 months · monthly snapshotTerminated~Mar 2020 – ~Sep 2020 · 6 months · monthly snapshotTerminated~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshotTerminated~Jan 2021 – ~Dec 2022 · 23 months · monthly snapshotTerminated~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshotTerminated~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotTerminated~Sep 2025 – present · 10 months · monthly snapshotTerminated

Change History

12 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jan 2023 — Jul 2024 [monthly]

    Terminated PHASE2

  5. Dec 2022 — Jan 2023 [monthly]

    Terminated PHASE2

▶ Show 7 earlier versions

  1. Jan 2021 — Dec 2022 [monthly]

    Terminated PHASE2

  2. Sep 2020 — Jan 2021 [monthly]

    Terminated PHASE2

  3. Mar 2020 — Sep 2020 [monthly]

    Terminated PHASE2

  4. Jun 2018 — Mar 2020 [monthly]

    Terminated PHASE2

  5. Jun 2017 — Jun 2018 [monthly]

    Terminated PHASE2

  6. Feb 2017 — Jun 2017 [monthly]

    Terminated PHASE2

  7. Jan 2017 — Feb 2017 [monthly]

    Terminated PHASE2

    First recorded

Sep 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Boston Children's Hospital
  • Children's Hospital of Philadelphia
  • Children's National Research Institute
  • Lucile Packard Children's Hospital
  • Mendel Tuchman
  • University Hospitals Cleveland Medical Center
  • University of California, Los Angeles
  • University of Colorado, Denver
Data source: Children's National Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations