deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT01625351

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

A Phase I Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

Sponsor: CURE Childhood Cancer, Inc.

Conditions Clear Cell Carcinoma Ewing Sarcoma Gastrointestinal Tumor Germ Cell Tumor Hepatic Tumor Lymphoma Melanoma Neuroblastoma Non-rhabdomyosarcoma Renal Cell Carcinoma Rhabdoid Tumor Rhabdomyosarcoma Wilms Tumor
Interventions Busulfan CliniMACS alemtuzumab fludarabine melphalan sirolimus stem cells
Updated 15 times since 2017 Last updated: Feb 4, 2026 Started: Aug 20, 2012 Primary completion: Feb 10, 2020 Completion: Feb 10, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01625351, this PHASE1 trial focuses on Clear Cell Carcinoma and Ewing Sarcoma and remains completed. Sponsored by CURE Childhood Cancer, Inc., it has been updated 15 times since 2012, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Sep 2017 · 4 months · monthly snapshot~Sep 2017 – ~Jun 2018 · 9 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Aug 2019 · 12 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Feb 2020 · 4 months · monthly snapshot~Feb 2020 – ~Oct 2020 · 8 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2026 · 17 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

15 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Feb 2026 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  5. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

▶ Show 10 earlier versions

  1. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1

  3. Oct 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE1

  5. Aug 2018 — Aug 2019 [monthly]

    Active Not Recruiting PHASE1

  6. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE1

  7. Sep 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  8. May 2017 — Sep 2017 [monthly]

    Recruiting PHASE1

  9. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1

  10. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Aug 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • CURE Childhood Cancer, Inc.
  • St. Jude Children's Research Hospital
Data source: St. Jude Children's Research Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations