deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT01683279

A Pediatric Trial of Genetically Modified Autologous T Cells Directed Against CD19 for Relapsed CD19+ Acute Lymphoblastic Leukemia

Pediatric Leukemia Adoptive Therapy (PLAT)-01: A Phase 1 Feasibility and Safety Study of Cellular Immunotherapy for Relapsed Pediatric CD19+ Acute Lymphoblastic Leukemia Using Autologous T-cells Lentivirally Transduced To Express a CD19-Specific Chimeric Antigen Receptor

Sponsor: Seattle Children's Hospital

Conditions B Cell Leukemia
Interventions Autologous CD19 CAR+ EGFTt + T cells
Updated 14 times since 2017 Last updated: Jun 12, 2025 Started: Mar 25, 2012 Primary completion: Jan 7, 2015 Completion: Jan 7, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates B Cell Leukemia and is currently ongoing. Seattle Children's Hospital leads this study, which shows 14 recorded versions since 2012 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Aug 2019 · 5 months · monthly snapshot~Aug 2019 – ~Feb 2020 · 6 months · monthly snapshot~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2022 · 13 months · monthly snapshot~Mar 2022 – ~May 2023 · 14 months · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – present · 12 months · monthly snapshot

Change History

14 versions recorded

  1. Jul 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2024 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  5. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

▶ Show 9 earlier versions

  1. Mar 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1

  4. Feb 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  5. Aug 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

  6. Mar 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE1

  7. Jun 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1

  8. Feb 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

  9. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Mar 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Seattle Children's Hospital
Data source: Seattle Children's Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations