A Study of Pinatuzumab Vedotin (DCDT2980S) Combined With Rituximab or Polatuzumab Vedotin (DCDS4501A) Combined With Rituximab or Obinutuzumab in Participants With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (NHL) (ROMULUS)
A Randomized, Open-Label, Multicenter, Phase II Trial Evaluating the Safety and Activity of Pinatuzumab Vedotin (DCDT2980S) in Combination With Rituximab or Polatuzumab Vedotin (DCDS4501A) in Combination With Rituximab and a Non-Randomized Phase Ib/II Evaluation of Polatuzumab Vedotin in Combination With Obinutuzumab in Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma
Sponsor: Genentech, Inc.
This PHASE1/PHASE2 trial investigates Diffuse Large B-Cell Lymphoma and Follicular Lymphoma and is currently completed. Genentech, Inc. leads this study, which shows 17 recorded versions since 2012 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
17 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE1/PHASE2
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Sep 2024 — Sep 2025 [monthly]
Completed PHASE1/PHASE2
-
Jul 2024 — Sep 2024 [monthly]
Completed PHASE1/PHASE2
Phase: PHASE1_PHASE2 → PHASE1/PHASE2
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Jan 2021 — Jul 2024 [monthly]
Completed PHASE1_PHASE2
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Mar 2020 — Jan 2021 [monthly]
Completed PHASE1_PHASE2
▶ Show 12 earlier versions
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Sep 2019 — Mar 2020 [monthly]
Completed PHASE1_PHASE2
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Jun 2019 — Sep 2019 [monthly]
Completed PHASE1_PHASE2
Status: Active Not Recruiting → Completed
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Feb 2019 — Jun 2019 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Nov 2018 — Feb 2019 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Sep 2018 — Nov 2018 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Jun 2018 — Sep 2018 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
May 2018 — Jun 2018 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Dec 2017 — May 2018 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Sep 2017 — Dec 2017 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Jul 2017 — Sep 2017 [monthly]
Active Not Recruiting PHASE1_PHASE2
-
Feb 2017 — Jul 2017 [monthly]
Active Not Recruiting PHASE1_PHASE2
Status: Recruiting → Active Not Recruiting
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1_PHASE2
First recorded
Sep 2012
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Genentech, Inc.
For direct contact, visit the study record on ClinicalTrials.gov .