deltatrials
Approved For Marketing EXPANDED_ACCESS NCT01724580

Compassionate Use Protocol for the Treatment of Autoinflammatory Syndromes

Compassionate Use Treatment Protocol I4V-MC-JAGA: Treatment of Conditions Expected to Benefit From JAK 1/2 Inhibition: CANDLE, CANDLE-Related Conditions, SAVI and Severe Juvenile Dermatomyositis

Sponsor: Eli Lilly and Company

Conditions Aicardi-Goutières Syndrome (AGS) Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy and Elevated Temperature (CANDLE) Juvenile Dermatomyositis (JDM) Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset During Infancy (SAVI)
Interventions Baricitinib
Updated 45 times since 2017 Last updated: Jan 15, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates Aicardi-Goutières Syndrome (AGS) and Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy and Elevated Temperature (CANDLE) and is currently ongoing. Eli Lilly and Company leads this study, which shows 45 recorded versions since 2026 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Jun 2017 · 3 months · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Apr 2018 · 6 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Aug 2020 · 22 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~May 2023 · 2 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – present · 18 months · monthly snapshot

Change History

45 versions recorded

  1. Feb 2025 — Present [monthly]

    Approved For Marketing

    Status: No Longer Available → Approved For Marketing

  2. Sep 2024 — Feb 2025 [monthly]

    No Longer Available

  3. Jul 2024 — Sep 2024 [monthly]

    No Longer Available

  4. Nov 2023 — Jul 2024 [monthly]

    No Longer Available

  5. Sep 2023 — Nov 2023 [monthly]

    No Longer Available

▶ Show 40 earlier versions

  1. Aug 2023 — Sep 2023 [monthly]

    No Longer Available

  2. Jul 2023 — Aug 2023 [monthly]

    No Longer Available

  3. Jun 2023 — Jul 2023 [monthly]

    No Longer Available

  4. May 2023 — Jun 2023 [monthly]

    No Longer Available

  5. Mar 2023 — May 2023 [monthly]

    No Longer Available

  6. Feb 2023 — Mar 2023 [monthly]

    No Longer Available

  7. Jan 2023 — Feb 2023 [monthly]

    No Longer Available

  8. Dec 2022 — Jan 2023 [monthly]

    No Longer Available

  9. Nov 2022 — Dec 2022 [monthly]

    No Longer Available

  10. Sep 2022 — Nov 2022 [monthly]

    No Longer Available

  11. Jul 2022 — Sep 2022 [monthly]

    No Longer Available

  12. Jun 2022 — Jul 2022 [monthly]

    No Longer Available

  13. May 2022 — Jun 2022 [monthly]

    No Longer Available

  14. Apr 2022 — May 2022 [monthly]

    No Longer Available

  15. Mar 2022 — Apr 2022 [monthly]

    No Longer Available

  16. Jan 2022 — Mar 2022 [monthly]

    No Longer Available

  17. Dec 2021 — Jan 2022 [monthly]

    No Longer Available

  18. Nov 2021 — Dec 2021 [monthly]

    No Longer Available

  19. Oct 2021 — Nov 2021 [monthly]

    No Longer Available

  20. Sep 2021 — Oct 2021 [monthly]

    No Longer Available

  21. Jun 2021 — Sep 2021 [monthly]

    No Longer Available

  22. May 2021 — Jun 2021 [monthly]

    No Longer Available

  23. Apr 2021 — May 2021 [monthly]

    No Longer Available

  24. Mar 2021 — Apr 2021 [monthly]

    No Longer Available

  25. Feb 2021 — Mar 2021 [monthly]

    No Longer Available

  26. Jan 2021 — Feb 2021 [monthly]

    No Longer Available

  27. Dec 2020 — Jan 2021 [monthly]

    No Longer Available

  28. Nov 2020 — Dec 2020 [monthly]

    No Longer Available

  29. Oct 2020 — Nov 2020 [monthly]

    No Longer Available

  30. Sep 2020 — Oct 2020 [monthly]

    No Longer Available

  31. Aug 2020 — Sep 2020 [monthly]

    No Longer Available

  32. Oct 2018 — Aug 2020 [monthly]

    No Longer Available

    Status: Available → No Longer Available

  33. Jun 2018 — Oct 2018 [monthly]

    Available

  34. Apr 2018 — Jun 2018 [monthly]

    Available

    Phase: NA → None

  35. Oct 2017 — Apr 2018 [monthly]

    Available NA

  36. Sep 2017 — Oct 2017 [monthly]

    Available NA

  37. Jun 2017 — Sep 2017 [monthly]

    Available NA

  38. Mar 2017 — Jun 2017 [monthly]

    Available NA

  39. Feb 2017 — Mar 2017 [monthly]

    Available NA

  40. Jan 2017 — Feb 2017 [monthly]

    Available NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations